CD147 is a surface glycoprotein expressed on a wide range of cells including hematopoietic and non-hematopoietic cells. However, it is enriched on the plasma membrane of many human cancer cells and is also shown to be upregulated in cells exhibiting resistance to chemotherapeutic agents. Glioblastomas are the most frequently occurring tumors of the brain and also the most aggressive type among Gliomas. These cells have shown to over express CD147 and it is associated with tumor invasion, metastasis and poor prognosis. The upstream region of CD147 gene contains GC rich sequences and binding sites for many transcription factors. Through this project, we are studying the transcriptional factors that modulate CD 147 expression in aggressive glioma cells.