Prophylactic potential of the extract of the bark of Terminalia arjuna (Roxb.ex.Dc.) Wight & Arn. In preventing osteoporosis –(DBT funded project: BT/PR7658/ BD/17/842/2013)

Osteoporosis is a silent epidemic and a major global health problem. Life-style of school going children contributes to obesity and precocious puberty in girls that predisposes them to osteoporosis and hypertension. An important contributor to such predisposition is Oxidatively modified lipids. These oxylipids induce oxidative stress and regulate molecular signaling that potentiates the pathogenesis of osteoporosis. A survey predicted that …

eM@n@gerProphylactic potential of the extract of the bark of Terminalia arjuna (Roxb.ex.Dc.) Wight & Arn. In preventing osteoporosis –(DBT funded project: BT/PR7658/ BD/17/842/2013)

Platelet associated Molecular Targets for inflammation, vascular integrity, Thrombocytopenia and Disease severity in Dengue infection- (DBT funded project BT/PR8628/MED/29/756/2013)

Recent studies suggest that dengue virus (DV) may induce thrombocytopenia via direct interactions with mega-karyocytes and platelets. However the precise mechanism accounting for thrombocytopenia in DV infection remains unclear. In Collaboration with JIPMER, the study aims to identify CD molecules that might be associated with the platelet pathology in dengue cases and to study the association of lipids with thrombocytopenia …

eM@n@gerPlatelet associated Molecular Targets for inflammation, vascular integrity, Thrombocytopenia and Disease severity in Dengue infection- (DBT funded project BT/PR8628/MED/29/756/2013)

Development of a novel egg shell based in vitro model for calcium mineralization.

Osteogenic differentiation along with other lineage specific differentiation is one of the widely employed methods to study stem cells under in vitro conditions. This project aims to develop an in vitro model using egg shell material to study osteogenic differentiation of stem cells like bone marrow derived mesenchymal stem cells.

benetboscoDevelopment of a novel egg shell based in vitro model for calcium mineralization.
eM@n@gerTo study the interplay of proinflammatory cytokines and chemokines associated with the innate immune system with concomitant microRNA expression profile from adipocytes and macrophages using cell lines under co-culture conditions mimicking obesity

To study the transcriptional control of CD147 expression in glioblastomas through cell lines -(DBT funded project6242-P71/RGCB/PMD/DBT/PJPH/2015)

CD147 is a surface glycoprotein expressed on a wide range of cells including hematopoietic and non-hematopoietic cells. However, it is enriched on the plasma membrane of many human cancer cells and is also shown to be upregulated in cells exhibiting resistance to chemotherapeutic agents. Glioblastomas are the most frequently occurring tumors of the brain and also the most aggressive type …

eM@n@gerTo study the transcriptional control of CD147 expression in glioblastomas through cell lines -(DBT funded project6242-P71/RGCB/PMD/DBT/PJPH/2015)