Osteoporosis is a silent epidemic and a major global health problem. Life-style of school going children contributes to obesity and precocious puberty in girls that predisposes them to osteoporosis and hypertension. An important contributor to such predisposition is Oxidatively modified lipids. These oxylipids induce oxidative stress and regulate molecular signaling that potentiates the pathogenesis of osteoporosis. A survey predicted that …
eM@n@gerProphylactic potential of the extract of the bark of Terminalia arjuna (Roxb.ex.Dc.) Wight & Arn. In preventing osteoporosis –(DBT funded project: BT/PR7658/ BD/17/842/2013)
Recent studies suggest that dengue virus (DV) may induce thrombocytopenia via direct interactions with mega-karyocytes and platelets. However the precise mechanism accounting for thrombocytopenia in DV infection remains unclear. In Collaboration with JIPMER, the study aims to identify CD molecules that might be associated with the platelet pathology in dengue cases and to study the association of lipids with thrombocytopenia …
eM@n@gerPlatelet associated Molecular Targets for inflammation, vascular integrity, Thrombocytopenia and Disease severity in Dengue infection- (DBT funded project BT/PR8628/MED/29/756/2013)
CD147 is a surface glycoprotein expressed on a wide range of cells including hematopoietic and non-hematopoietic cells. However, it is enriched on the plasma membrane of many human cancer cells and is also shown to be upregulated in cells exhibiting resistance to chemotherapeutic agents. Glioblastomas are the most frequently occurring tumors of the brain and also the most aggressive type …
eM@n@gerTo study the transcriptional control of CD147 expression in glioblastomas through cell lines -(DBT funded project6242-P71/RGCB/PMD/DBT/PJPH/2015)
Central Inter-Disciplinary Research Facility (CIDRF), DSIR, Govt. of India recognized research center to foster research emanating from ‘bed side’ to ‘bench’ and back to ‘bed side’ enabled by its association to two medical (MGMCRI, SSSMCRI) and one dental (IGIDS) institution with hospitals. CIDRF is intended to be an inter-disciplinary open forum for interaction between scientists and clinicians taking medical research to molecular levels so that clinical practice gets the strongest evidence base and support.
To fulfil our mission of ‘bedside’ to ‘bench’ to ‘bedside’ in healthcare at CIDRF we, the group of enthusiastic, young and competent researchers drawn from different disciplines of bio-medical sciences are into both exploration at the fundamental level and application at the translational level.